Immediately after switching the page, it will work with CSR.
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And yes, being able to jettison a pre-processor for frontend things is a very necessary thing, and unless the designers have accounted for this (I only know of create-react-app having a "jettison" feature, and then - just) you are in for a heap of fun if you need to resurrect a 5-years old app with its dev environment.
I don't think doing layout using other means (formatting specifiers? spacer elements?) would have been that much different, given that it's constraints all the way. The difficult bit is that the layout is not fixed - and it's a pain either way you do it, doing things well in InterfacerBuilder.app was also a struggle.
Yes, "center things" is ridiculous because you have to do it "4 different ways" with different tradeoffs - and there are some areas where things are still very painful (text-box-trim just now becoming available). But "failed"?.. that is a bit harsh.