Need to read this asap, but 6.5% is an exceedingly small effect size and not robust given many confounding developmental and technical factors. The typical coefficient of error between volumes of even large brain regions in genetically identical mice is usually well over 5%. And I suspect the transgene was only tested on one genetic background—-usually C57BL/6J.

Will emend this post tomorrow with corrections after reading carefully. I can say with reasonsble assurance that no one has measured and weighed more mouse brains than I have ;-) (except you John Wong)

Meta comment: 11/13 comments currently are pop-culture references (Flowers for Algernon, Pinky and the Brain, other movies) or generic phrases and only 2 comments relate to the actual article. I've been on HN for over a decade, and this is the worst it's ever been.

And thus began the Mousepocalypse...

(:shrug: I get it... Sore point... The apocalypse isn't a humorous thing to joke about, what with it being in the midst of actually happening and all ... but if I don't try to find myself a little giggle here and there once in a while I'ma literally go insane, so whatever. Down-vote away. Don't really care anymore.)

Heck, if you give mice all of our DNA, they’ll become exactly like us!

But are they any smarter?